Siah2 ELISA Kit for Mouse(Mus musculus) | EIAab.comSiah2 ELISA Kit for Mouse(Mus musculus)

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Siah2 (Gene name),

E3 ubiquitin-protein ligase SIAH2 (Protein name ), SIAH2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Siah2;

Protein name:

E3 ubiquitin-protein ligase SIAH2;

Alternative:

Seven in absentia homolog 2(Siah-2;mSiah2);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Interacts with UBE2E2. Interacts with VAV1, without mediating its ubiquitin-mediated degradation. Interacts with CACYBP/SIP. Probable component of some large E3 complex possibly composed of UBE2D1, SIAH2, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with UBE2I. Interacts with PEG10, which may inhibit its activity. Interacts with EGLN2 and SNCAIP (By similarity). Interacts with PEG3.

Function:

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Promotes monoubiquitination of SNCA (By similarity). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not.

Subcellular Location:

Cytoplasm Nucleus Predominantly cytoplasmic (By similarity). Partially nuclear.

Protein Attributes:

Sequence length:

325

Sequence:

50:

100:

150:

200:

250:

300:

325:

DTAIAHLFAD | NGNLGINVTI | STCCQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.2847

SMR:

Q06986

KEGG:

mmu:20439

String:

Q06986

Pfam:

PF03145

Uniprot:

Q06986

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ELISA Kit for Mouse E3 ubiquitin-protein ligase SIAH2

Cat.:

E5526h

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Manual:

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96T

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ELISA Kit for Mouse E3 ubiquitin-protein ligase SIAH2

Cat.:

E5526r

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96T

ELISA Kit for Mouse E3 ubiquitin-protein ligase SIAH2

Cat.:

E5526m

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96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase SIAH2

Cat.:

U5526h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase SIAH2

Cat.:

U5526r

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Packing:

96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase SIAH2

Cat.:

U5526m

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Packing:

96T

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase SIAH2

Cat.:

P5526Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase SIAH2

Cat.:

P5526Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase SIAH2

Cat.:

P5526Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase SIAH2

Protein for Mouse E3 ubiquitin-protein ligase SIAH2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina)."
Della N.G. , Senior P.V. , Bowtell D.D.L.
Development117:1333-1343(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
strain: Swiss.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
3.

"Expression of Siah-2, a vertebrate homologue of Drosophila sina, in germ cells of the mouse ovary and testis."
Della N.G. , Bowtell D.D.L. , Beck F.
Cell Tissue Res.279:411-419(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
4.

"Proteasomal regulation of nuclear receptor corepressor-mediated repression."
Zhang J. , Guenther M.G. , Carthew R.W. , Lazar M.A.
Genes Dev.12:1775-1780(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN DEGRADATION OF NCOR1
5.

"Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis."
Relaix F. , Wei X. , Li W. , Pan J. , Lin Y. , Bowtell D.D. , Sassoon D.A. , Wu X.
Proc. Natl. Acad. Sci. U.S.A.97:2105-2110(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PEG3
6.

"Alteration of the stability of Bag-1 protein in the control of olfactory neuronal apoptosis."
Sourisseau T. , Desbois C. , Debure L. , Bowtell D.D.L. , Cato A.C.B. , Schneikert J. , Moyse E. , Michel D.
J. Cell Sci.114:1409-1416(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN DEGRADATION OF BAG1
7.

"Normal p53 function in primary cells deficient for Siah genes."
Frew I.J. , Dickins R.A. , Cuddihy A.R. , Del Rosario M. , Reinhard C. , O'Connell M.J. , Bowtell D.D.L.
Mol. Cell. Biol.22:8155-8164(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
8.

"Generation and analysis of Siah2 mutant mice."
Frew I.J. , Hammond V.E. , Dickins R.A. , Quinn J.M.W. , Walkley C.R. , Sims N.A. , Schnall R. , Della N.G. , Holloway A.J. , Digby M.R. , Janes P.W. , Tarlinton D.M. , Purton L.E. , Gillespie M.T. , Bowtell D.D.L.
Mol. Cell. Biol.23:9150-9161(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome."
Fanelli M. , Fantozzi A. , De Luca P. , Caprodossi S. , Matsuzawa S. , Lazar M.A. , Pelicci P.G. , Minucci S.
J. Biol. Chem.279:5374-5379(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN DEGRADATION OF PML
10.

"Regulation of the ring finger E3 ligase Siah2 by p38 MAPK."
Khurana A. , Nakayama K. , Williams S. , Davis R.J. , Mustelin T. , Ronai Z.
J. Biol. Chem.281:35316-35326(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-24 AND SER-29;FUNCTION

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